A catalytic and iterative route to beta-substituted esters via highly enantioselective conjugate addition of dimethylzinc to unsaturated malonates

摘要

Using the chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition of dimethylzinc to acyclic unsaturated malonates, enantioselectivities of up to 98% have been obtained for the first time. An iterative and stereodivergent route to 3,5-dimethyl esters that takes advantage of this asymmetric catalysis has been developed.